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Understanding the limitations of non-pharmaceutical interventions (NPIs) during the Covid-19 pandemic

The UK and many other countries saw the implementation of numerous non-pharmaceutical interventions (NPIs) during the Covid-19 pandemic. Policy-makers, clinicians and public health specialists need to be more aware of the limitations of observational studies in evaluating non- NPIs. The lack of high-quality randomised controlled trials (RCTs) during the Covid-19 made it difficult to isolate the specific effects of individual NPIs and disentangle them from the complex interplay of different interventions. While observational studies provided rapid insights in an evolving crisis, they also presented challenges due to confounding factors and the concurrent implementation of multiple NPIs. Prioritising adaptive frameworks for real-time RCTs, particularly cluster-randomized trials, in future health crises could strengthen the evidence base and provide more robust insights for policymakers. Although the UK has a good public health data infrastructure compared to many other countries, it can
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Cardiovascular risks in people with long-term conditions

People with many long-term conditions are at increased risk of cardiovascular disease. If you or someone you care about is living with a long-term condition, here are some practical steps people can take to reduce their risk: 1. Attend for Scheduled Check-Ups: Make sure you attend for any scheduled check-ups. For example, to check your blood pressure, weight, blood sugar levels and cholesterol; or to review your medication. 2. Healthy Lifestyle Choices: Focus on a healthy diet, regular physical activity and avoiding smoking; all of which can reduce the risk of cardiovascular disease. For exercise, you should aim for at least 150 minutes of moderate intensity activity a week or 75 minutes of vigorous intensity activity a week. But even small changes – such as a modest increase in the amount of exercise you take each day – can have positive benefits. A diet rich in fruits, vegetables and whole grains and with less intake of processed foods and sugary drinks is also helpful for your hea
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Understanding Vascular Risks in People with Multiple Sclerosis (MS)

Multiple sclerosis (MS) is a complex neurological condition that affects the central nervous system. While much of the focus on MS is often on the symptoms related to the nervous system, recent research has shed light on another important aspect: the increased risk of vascular diseases, such as diabetes and hypertension, in people living with MS (PwMS). Let's take a closer look at what this means and how it impacts overall health based on the findings of a recent paper from my team published in the Multiple Sclerosis Journal . What the Research Shows A large study conducted between 1987 and 2018 looked at the health records of over 12,000 people with MS and compared them with over 70,000 individuals without MS. The findings were significant: Increased Risk of Diabetes : People living with MS have a higher risk of developing type 2 diabetes after being diagnosed with MS. Over 10 years, the incidence rate of diabetes was notably higher in people with MS compared to those without. Wom
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Preparing for Future Health Shocks: Lessons from the COVID-19 Pandemic

The COVID-19 pandemic was a profound global health crisis that exposed vulnerabilities in our public health systems and forced rapid adaptations worldwide. In the absence of effective pharmaceutical solutions at the pandemic's onset, non-pharmaceutical interventions (NPIs) such as physical distancing, mask-wearing, and lockdowns became essential tools to mitigate the spread of SARS-CoV-2. While NPIs were crucial in reducing transmission and preventing healthcare system overload, their implementation came with significant social, economic, and psychological costs. Reflecting on these measures - as we do in our recent article in the British Medical Journal - offers valuable insights into preparing for future health shocks. Evaluating the Effectiveness of Non-Pharmaceutical Interventions NPIs aim to limit person-to-person contact and control the spread of infectious diseases, but they are not without challenges. The simultaneous application of multiple interventions during the pandem
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Guidance on Writing a Scientific Abstract and Lay Summary

Increasingly, academic dissertations and papers require a lay summary as well as a scientific abstract. It is important to distinguish between the style and content of the scientific abstract and the lay summary. These sections serve different purposes and are intended for different audiences. In this blog, I aim to help you write both effectively, supported by examples. Scientific Abstract The scientific abstract is written for experts, researchers and professionals in your field. It is a concise summary of your research that includes the background, methods, key findings, and implications. The language used is technical and generally assumes the reader has a good understanding of the subject. What to Include in the Abstract: Background/Context: Briefly explain the problem your research addresses. Aim: State the specific objectives of the study. Methods: Summarise the methods used, including any important experimental techniques or data sources. Results: Clearly outline the main findi
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What are the benefits of a high-fibre diet?

A high-fibre diet is crucial for maintaining overall health and well-being. Fibre, a type of carbohydrate that the body cannot digest, plays a key role in various bodily functions. Here are some of the primary benefits of incorporating more fibre into your diet: 1. Improved Digestive Health:  Fibre is essential for maintaining a healthy digestive system. It adds bulk to the stool, which helps prevent constipation and promotes regular bowel movements. Insoluble fibre, found in foods like whole grains and vegetables, passes through the digestive tract relatively intact and speeds up the passage of bowel contents. 2. Helps with Weight Management:  High-fibre foods can be more filling than low-fibre foods which help controls appetite and reduce overall calorie intake. By slowing the digestion process fibre can make you feel fuller for longer thus aiding in weight management and reducing the likelihood of overeating. 3. Lower Cholesterol Levels:  Soluble fibre, found in foods like oats, bea
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Understanding the Impact of Inhaled Corticosteroids on Adverse Events in People with Asthma

Asthma is a chronic condition that affects many millions of people worldwide, making it difficult for them to breathe due to inflamed airways. Inhaled corticosteroids (ICS) are a cornerstone of asthma treatment, significantly improving patients' quality of life by reducing symptoms, preventing asthma attacks, and improving lung function. However, while the benefits of ICS are well-established, there are concerns about potential adverse effects, particularly at higher doses. The Role of Inhaled Corticosteroids Inhaled corticosteroids are anti-inflammatory medications that are commonly prescribed to manage asthma. They work by reducing inflammation in the airways, making it easier to breathe and reducing the frequency of asthma exacerbations. According to current guidelines, patients should use the lowest effective dose of ICS to manage their asthma effectively. Key Findings from Our Recent Research Study Our recent study in the American Journal of Respiratory and Critical Care Medic
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